histone octamer function
Previously, it has been reported that nucleosomes can slide in a non-catalyzed way on various weakly positioning DNA sequences at physiological or slightly elevated temperaturesConformational rearrangement of the histone octamer is required for nucleosome sliding.
Histone H3 N‐terminal mutations allow hyperactivation of the yeast Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission
Nucleosomes are highly dynamic and are remodeled with the help of ATP-dependent remodeling factors.
H2B dimer Internet Explorer). Zhou, C. Y., Johnson, S. L., Gamarra, N. I. Positioning and stability of nucleosomes on MMTV 3’LTR sequences. Role of histone tyrosines in nucleosome formation and histone–histone interaction The SWI–SNF complex: a chromatin remodeling machine? Lowary, P. T. & Widom, J. Nucleosome packaging and nucleosome positioning of genomic DNA. & Davey, C. A. DNA stretching and extreme kinking in the nucleosome core.
& Davey, C. A. Edayathumangalam, R. S., Weyermann, P., Dervan, P. B., Gottesfeld, J. M. & Luger, K. Nucleosomes in solution exist as a mixture of twist-defect states. & Cairns, B. R. Chromatin remodeling through directional DNA translocation from an internal nucleosomal site. A cell cycle checkpoint monitors cell morphogenesis in budding yeast Andrews, A. J. Shim, Y., Duan, M.-R., Chen, X., Smerdon, M. J.
S.B.
Histone octamer function in vivo : mutations in the dimer–tetramer interfaces disrupt both gene activation and repression Maria Soledad Santisteban Department of Microbiology and University of Virginia Cancer Center, Box 441 Jordan Building, School of …
and JavaScript.Nucleosomes, the basic unit of chromatin, package and regulate expression of eukaryotic genomes. Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure. assisted with electron microscopy. Liu, X., Li, M., Xia, X., Li, X. Dechassa, M. L. et al. In the Class 2 structure, we observed the movement of DNA with the largest movements in the SHL 2 region (Fig. Kurumizaka, H. & Wolffe, A. P. Sin mutations of histone H3: influence on nucleosome core structure and function. M.S. In the meantime, to ensure continued support, we are displaying the site without styles We thank Sigrun Jaklin for excellent technical assistance, Segolene Demolin for the help with the histone purifications, and Nikolai Czech for the help with the DNA purifications. You are using a browser version with limited support for CSS. Deformation of the histone octamer in the Class 2 structure generates the strain that leads to translocation of the DNA by the octamer as observed in the Class 3 structure.
Prior, C. P., Cantor, C. R., Johnson, E. M., Littau, V. C. & Allfrey, V. G. Reversible changes in nucleosome structure and histone H3 accessibility in transcriptionally active and inactive states of rDNA chromatin.
The structure of DNA in the nucleosome core.
The H4 tail is essential for enzyme-driven chromatin remodeling, and the chromatin remodelers ISWI and Chd1 require the basic patch of the H4 tail (K16-R17-H18-R19) for the activityIn our recent study ~ 10% of nucleosomes had unwrapped DNAIn all crystal structures of the NCP, the histone octamer is found in the same conformationDNA for nucleosome reconstitution was PCR amplified from a plasmid containing the strong positioning 601 DNA sequenceThe glutaraldehyde was added to a final concentration of 0.1% (v/v) and the samples were incubated for 5 min at the room temperature for cryo-EM grid preparation. Construction and genetic characterization of temperature‐sensitive mutant alleles of the yeast actin gene To obtain The octamer consists of a (H3–H4) 2 tetramer associated with two H2A–H2B dimers.
Mutations that affect chromosomal proteins in yeast
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